Chest keloids: effect of surgical excision and adjuvant radiotherapy on recurrence, a systematic review and meta?analysis

Background Chest keloids are a difficult sub-group of scars to treat, likely secondary the high wound tension in area that promotes excessive fibroblast proliferation and collagen deposition. Excision adjuvant radiotherapy has been demonstrated as an efficacious treatment for general, but no meta-analysis exists support claims chest keloids. This study aims identify rate recurrence after surgical resection on patients with Methods A search was performed using Embase, MEDLINE, Pubmed Cochrane database 22 December 2018 terms ‘radiotherapy’, ‘keloid’ ‘chest’. Papers included met prospectively designed inclusion criteria assessed by multiple investigators. Results Twelve studies, including 1 randomized controlled trial, were total 400 keloid scar managed excision radiotherapy. Overall pooled-estimate 22% (95% CI 12–32%). Meta-regression did not demonstrate significant effect method closure, type radiotherapy, dose (BED10) type. Conclusion represents effective keloids, however sufficient prospective data, trials, yet exist these findings. Further studies analysis location required add pool literature can be added this meta-analysis.